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Wounding triggers MIRO-1 dependent mitochondrial fragmentation that accelerates epidermal wound closure through oxidative signaling.
Organisms respond to tissue damage through the upregulation of protective responses which restore tissue structure and metabolic function. Mitochondria are key sources of intracellular oxidative metabolic signals that maintain cellular homeostasis. Here we report that tissue and cellular wounding triggers rapid and reversible mitochondrial fragmentation. Elevated mitochondrial fragmentation either in fzo-1 fusion-defective mutants or after acute drug treatment accelerates actin-based wound closure. Wounding triggered mitochondrial fragmentation is independent of the GTPase DRP-1 but acts via the mitochondrial Rho GTPase MIRO-1 and cytosolic Ca2+. The fragmented mitochondria and accelerated wound closure of fzo-1 mutants are dependent on MIRO-1 function. Genetic and transcriptomic analyzes show that enhanced mitochondrial fragmentation accelerates wound closure via the upregulation of mtROS and Cytochrome P450. Our results reveal how mitochondrial dynamics respond to cellular and tissue injury and promote tissue repair
Photonic realization of topologically protected bound states in domain-wall waveguide arrays
We present an analytical theory of topologically protected photonic states
for the two-dimensional Maxwell equations for a class of continuous periodic
dielectric structures, modulated by a domain wall. We further numerically
confirm the applicability of this theory for three-dimensional structures.Comment: 6 pages, 5 figures. To appear in the Phys. Rev.
Strongly coupled slow-light polaritons in one-dimensional disordered localized states
Cavity quantum electrodynamics advances the coherent control of a single
quantum emitter with a quantized radiation field mode, typically piecewise
engineered for the highest finesse and confinement in the cavity field. This
enables the possibility of strong coupling for chip-scale quantum processing,
but till now is limited to few research groups that can achieve the precision
and deterministic requirements for these polariton states. Here we observe for
the first time coherent polariton states of strong coupled single quantum dot
excitons in inherently disordered one-dimensional localized modes in slow-light
photonic crystals. Large vacuum Rabi splittings up to 311 {\mu}eV are observed,
one of the largest avoided crossings in the solid-state. Our tight-binding
models with quantum impurities detail these strong localized polaritons,
spanning different disorder strengths, complementary to model-extracted pure
dephasing and incoherent pumping rates. Such disorder-induced slow-light
polaritons provide a platform towards coherent control, collective
interactions, and quantum information processing.Comment: 17 pages, 5 figures and supplementary informatio
Harnessing high-dimensional hyperentanglement through a biphoton frequency comb
Quantum entanglement is a fundamental resource for secure information
processing and communications, where hyperentanglement or high-dimensional
entanglement has been separately proposed towards high data capacity and error
resilience. The continuous-variable nature of the energy-time entanglement
makes it an ideal candidate for efficient high-dimensional coding with minimal
limitations. Here we demonstrate the first simultaneous high-dimensional
hyperentanglement using a biphoton frequency comb to harness the full potential
in both energy and time domain. The long-postulated Hong-Ou-Mandel quantum
revival is exhibited, with up to 19 time-bins, 96.5% visibilities. We further
witness the high-dimensional energy-time entanglement through Franson revivals,
which is observed periodically at integer time-bins, with 97.8% visibility.
This qudit state is observed to simultaneously violate the generalized Bell
inequality by up to 10.95 deviations while observing recurrent
Clauser-Horne-Shimony-Holt S-parameters up to 2.76. Our biphoton frequency comb
provides a platform in photon-efficient quantum communications towards the
ultimate channel capacity through energy-time-polarization high-dimensional
encoding
Near-infrared Hong-Ou-Mandel interference on a silicon quantum photonic circuit
Near-infrared Hong-Ou-Mandel quantum interference is observed in silicon
nanophotonic directional couplers with raw visibilities on-chip at 90.5%.
Spectrally-bright 1557-nm two-photon states are generated in a
periodically-poled KTiOPO4 waveguide chip, serving as the entangled photon
source and pumped with a self-injection locked laser, for the photon
statistical measurements. Efficient four-port coupling in the communications
C-band and in the high-index-contrast silicon photonics platform is
demonstrated, with matching theoretical predictions of the quantum interference
visibility. Constituents for the residual quantum visibility imperfection are
examined, supported with theoretical analysis of the sequentially-triggered
multipair biphoton contribution and techniques for visibility compensation,
towards scalable high-bitrate quantum information processing and
communications.Comment: 15 pages, 6 figure
Nonlocal cancellation of multi-frequency-channel dispersion
We present an investigation of the temporal correlation of time-energy entangled photon pairs propagating through multi-frequency-channel dispersive media, in which photon spectra spread over multiple discrete frequency channels with dispersions. We have observed more complex coincidence structures including double coincidence envelopes and dependence on frequency detuning that are absent in the single-channel case. Our results on the correlation of the time-energy photonic entanglement in dispersive media with channel divisions would impact the fields of quantum metrology and communication.United States. Defense Advanced Research Projects Agency. Information in a Photon Program (Army Research Office Grant W911NF-10-1-0416
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